Manufacturer: Panacea Biotec Ltd
Salt Composition : Zoledronic acid(4mg)
Zoletrust Injection is given by a doctor or nurse. How much you are given, and how often, will be decided by your doctor. It may just be a single injection or you may need regular injections depending upon your underlying condition. Your doctor will ask you to drink plenty of water before the injection, to avoid getting dehydrated. It may take several days to get the full benefit of this drug. Zoletrust Injection is only part of a treatment program that may also include changes to your diet and taking calcium and vitamin supplements.
Zoletrust Injection works by increasing the density of the bones which helps in preventing osteoporosis. In addition to that, it helps to treat high calcium levels in the blood caused due to secondary bone cancer. Also, it is helpful in treating metastasis of bone which is caused due to breast cancer.
Zoledronic plasma disposition was multiphasic, with half-lives of 0.2 and 1.4 hours representing an early, rapid decline of concentrations from the end-of- infusion Cmax to < 1% of Cmax at 24 hours postdose and half-lives of 39 and 4526 hours describing subsequent phases of very low.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zoletrust
Headache
Back pain
Musculoskeletal (bone, muscle or joint) pain
Heartburn
Diarrhea
Nausea
Breathlessness
Fatigue
Constipation
Bone pain
Vomiting
Fever
Anemia (low number of red blood cells)
low amount of magnesium in the blood
low amount of phosphate in the blood
low amount of calcium in the blood
dehydration
inflammation of the tissues surrounding a tooth
acute kidney failure
joint pain
muscle pain
pregnancy
a patient who is producing milk and breastfeeding
portions of the jaw bone to die from lack of blood circulation
invasive dental procedure
chronic kidney disease stage 4 (severe)
chronic kidney disease stage 5 (failure)
kidney disease with likely reduction in kidney function
an unusual and spontaneous bone break in the upper leg
Zoletrust Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Caution is advised when consuming alcohol with Zoletrust Injection. Please consult your doctor.
Zoletrust Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Use with caution
Below 9years: Contraindicated
Zoledronic Acid Injection is indicated for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy.
aminoglycosides (e.g., gentamicin, tobramycin)
calcitonin.
diuretics (water pills; e.g., hydrochlorothiazide, furosemide)
non-steroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
phosphate supplements.
Kindly do not self administer.
Store below 30°C
If you miss a dose of Zoletrust Injection. Please consult your doctor.
Consult a doctor before taking any medicines.
You have been prescribed Zoletrust Injection for the treatment of osteoporosis.
It may also be used to treat high blood calcium levels (hypercalcemia) or bone damage and pain that may occur with cancer.
It is given by injection into a vein, usually over at least 15 minutes or as directed by your doctor.
Drink plenty of fluids to prevent dehydration and kidney damage.
It can lower the level of calcium in the blood. Take calcium and vitamin D supplements as suggested by your doctor.
You may develop fever or flu like symptoms, such as chills, tiredness and weakness. These are usually temporary and should go away after a few days. You may take a pain reliever/fever reducer to prevent or treat these symptoms.
Zoletrust Injection may cause a rare condition called osteonecrosis of the jaw. Have regular dental check-ups and inform your doctor if you develop sudden pain in your jaw.
Your doctor will monitor your response to Zoletrust Injection by testing your bone mineral density (BMD). This is usually done every 1-3 years.
Do not take Zoletrust Injection if you are pregnant or breastfeeding.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Q. What is Zoletrust Injection? What is it used for?
Zoletrust Injection belongs to a class of medicines called bisphosphonates that prevents abnormal breakdown of the bones. Zoletrust Injection is used to prevent and treat osteoporosis and fractures in people with metastatic cancer (a cancer which spreads to newer areas of the body). It may also be used to treat hypercalcemia (elevated blood calcium levels).
Q. How does Zoletrust Injection work?
Zoletrust Injection works by increasing the density of the bones which helps in preventing osteoporosis. In addition to that, it helps to treat high calcium levels in the blood caused due to secondary bone cancer. Also, it is helpful in treating metastasis of bone which is caused due to breast cancer.
Q. How long should I take Zoletrust Injection?
Zoletrust Injection should be taken in the dose and duration advised by your doctor. The medicine takes around 6 month to show its maximum benefits on bones. However, in some cases, the doctor may suggest Zoletrust Injection for a longer duration. The exact duration will depend on the condition you are being treated for.
Q. How is Zoletrust Injection administered?
Zoletrust Injection should be administered by a trained healthcare professional or a doctor only and should not be self-administered. The dose will depend on the condition you are being treated for and will be decided by your doctor. Follow your doctor’s instructions carefully to get maximum benefit from Zoletrust Injection.
Q. Why can you not lie down after taking Zoletrust Injection?
One should not lie down after taking Zoletrust Injection as there is a possibility that the medication might come back up into the esophagus (food pipe). Due to this the esophagus may also get damaged. Staying upright will help the medicine to settle down quickly in your stomach and prevent side effects like heartburn and pain.
Q. Is Zoletrust Injection safe?
Zoletrust Injection is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Q. What other lifestyle changes should I make?
To get maximum benefit from Zoletrust Injection, there are certain lifestyle changes that you must adhere to. Include some calcium or Vitamin D rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight which in turn improve bone health.
