Manufacturer: Mankind Pharma Ltd
Salt Composition : Vildagliptin(50mg)
Strip of 10 Tablet
(Inclusive of all taxes)
Zukanorm 50 Tablet is a medicine used to treat type 2 diabetes mellitus. It is used together with a healthy diet and regular exercise to control blood sugar levels. This helps to prevent serious complications of diabetes like kidney damage and blindness.
Zukanorm 50 Tablet is normally prescribed when diet and exercise alone or other medicines do not prove sufficient to control your blood sugar level. It may prescribe alone or in combination with other diabetes medicines. It can be taken with or without food. The dose will depend on your condition and blood sugar levels. Use it strictly as advised by your doctor.
You should take it regularly at the same time each day to get the most benefit. Do not stop taking the medicine unless advised by your doctor. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.
The most common side effects of Zukanorm 50 Tablet include hypoglycemia, tremor, headache, dizziness, fatigue, and nausea. It is important to recognize the symptoms of hypoglycemia (such as lightheadedness, sweating, dizziness, fainting, and dry mouth) and know how to deal with it. You can carry sugar or glucose candy and have them to control your symptoms if you experience any. Contact your doctor if the side effects do not go away or worry you.
Before taking this medicine, let your doctor know if you have ever had kidney disease, heart disease, or pancreas problems. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines you are taking may interfere with this medicine's working. So, make sure your doctor knows about all the other medicines you are using. Limit your alcohol intake while taking this medicine because it can increase your risk of developing low blood sugar levels. You may need regular tests such as kidney function and blood glucose levels to check that the medicine is working properly.
Vildagliptin binds covalently to the catalytic site of DPP-4, eliciting prolonged enzyme inhibition. This raises intact GLP-1 levels, both after meal ingestion and in the fasting state. Vildagliptin has been shown to stimulate insulin secretion and inhibit glucagon secretion in a glucose-dependent manner.
Vildagliptin was rapidly absorbed, exhibiting a median tmax of 1.5 to 2 hours at all doses. Across the dose range of 25 to 200 mg, mean elimination half-life (t1/2) showed a trend toward increased values with increasing dose
Hypoglycemia (low blood glucose level)
Tremors
Headache
Dizziness
Fatigue
Nausea
Contraindicated in patients with type 1 diabetes, diabetic ketoacidosis, severe liver impairment, during pregnancy and breastfeeding
Zukanorm 50 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
It is not known whether it is safe to consume alcohol with Zukanorm 50 Tablet. Please consult your doctor.
Zukanorm 50 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Vildagliptin is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus: as monotherapy in patients in whom metformin is inappropriate due to contraindications or intolerance
Novartis' Galvus (vildagliptin) is a member of a class of oral antidiabetic agents known as dipeptidyl peptidase IV inhibitors (DPP-IV) inhibitors or 'incretin enhancers
Swallow it as a whole. Do not chew, crush or break it. Zukanorm 50 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Store below 30°C
If you miss a dose of Zukanorm 50 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Consult a doctor before taking any medicines
Zukanorm 50 Tablet should be taken at the same time every day since this helps you remember to take it.
It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor and anxiety.
Be careful while driving or operating machinery until you know how Zukanorm 50 Tablet affects you.
Your doctor may check your kidney and liver function before starting treatment and regularly thereafter. Inform your doctor if you develop symptoms such as abdominal pain, fatigue, loss of appetite, darkened urine or yellowing of the eyes or skin (jaundice).
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zukanorm 50 Tablet may be taken with or without food, but it is better to take it at a fixed time.
Q. When should I take Zukanorm 50 Tablet?
You can take Zukanorm 50 Tablet tablets before, with or after meals. If you have been prescribed to take this medicine once daily, then take it in the morning. In case you have to take it twice daily, then you should prefer taking the first dose in the morning and the second dose in the evening.
Q. Does Zukanorm 50 Tablet cause hypoglycemia?
Yes, Zukanorm 50 Tablet may cause hypoglycemia (low blood sugar), but the chances are lesser as compared to other antidiabetic drugs. Evidence suggests that treatment with Zukanorm 50 Tablet has been shown to cause hypoglycemia in very rare cases. The risk is low even in those who are prone to hypoglycemia like elderly people or people being treated with insulin. However, the chance of hypoglycemia increases if Zukanorm 50 Tablet is taken along with other antidiabetic drugs.
Q. Does Zukanorm 50 Tablet cause weight gain?
No, Zukanorm 50 Tablet does not cause weight gain. Moreover, medicines, such as Zukanorm 50 Tablet, are generally supposed to decrease weight since they act by increasing satiety (feeling of fullness) and delaying emptying of the stomach. This further decreases hunger, restricting the patient from eating more than required.
Q. Is Zukanorm 50 Tablet the same as sitagliptin?
No, Zukanorm 50 Tablet is not the same as Sitagliptin, but both drugs belong to the same class. Additionally, these two drugs have a similar mechanism of decreasing blood glucose levels.
