Manufacturer: Zydus Cadila
Salt Composition : Gemcitabine(200mg)
Zygem 200mg Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, hair loss and low blood platelets. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Gemcitabine is an antimetabolite ranking among the most prescribed anticancer drugs worldwide. This nucleoside analog exerts its antiproliferative action after tumoral conversion into active triphosphorylated nucleotides interfering with DNA synthesis and targeting ribonucleotide reductase.
Gemcitabine is a hydrophilic molecule, and three nucleoside transporters mediate most of its uptake into cells: SLC29A1 SLC28A1, and SLC28A3. Gemcitabine is also a pro-drug that requires serial phosphorylation by multiple kinases to become pharmacologically active.
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zygem
Nausea
Vomiting
Loss of appetite
Hair loss
Low blood platelets
Allergic reaction
Breathlessness
Decreased white blood cell count
Increased liver enzymes
Anemia (low number of red blood cells)
Flu-like symptoms
Blood in urine
Skin rash
Protein in urine
Gemcitabine Injection is contraindicated in patients with a known hypersensitivity to gemcitabine. Reactions include anaphylaxis [see Adverse Reactions (6. 1)]. If you provide additional keywords, you may be able to browse through our database of Scientific Response Documents.
Zygem 200mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Zygem 200mg Injection may cause excessive drowsiness with alcohol.
Zygem 200mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Gemcitabine is indicated for treatment of patients with locally advanced or metastatic adenocarcinoma of the pancreas. Gemcitabine, in combination with cisplatin is indicated as first line treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).
Gemcitabine has serious interactions with the following drugs:
adenovirus types 4 and 7 live, oral.
cedazuridine.
influenza virus vaccine quadrivalent, adjuvanted.
influenza virus vaccine trivalent, adjuvanted.
palifermin.
tofacitinib.
Kindly do not self administer.
Store below 30°C
Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
Your doctor or nurse will give you this medicine. Kindly do not self administer.
