Multiple endocrine neoplasia

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Multiple endocrine neoplasia (MEN) comprises two different genetic diseases in which point mutations of the MEN1 gene (in MEN I syndrome) or the RET gene (in MEN II syndrome) result in hyperplasia or tumor formation (or both) in several different endocrine organs.



Bone pain.

Broken bones.

Kidney stones.

Ulcers in the stomach or intestines.


Multiple endocrine neoplasia is caused by gene mutations that are handed down in families. If you have any of the MEN syndromes, your children have a 50% chance of developing the disease.

Mutations in the MEN1, RET, and CDKN1B genes can cause multiple endocrine neoplasia. Mutations in the MEN1 gene cause multiple endocrine neoplasia type 1. This gene provides instructions for producing a protein called menin.

Risk factors


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 MEN1 causes tumors to develop in endocrine glands and other parts of the body. Although most of these tumors are noncancerous, they can cause the affected glands to increase in size and become overactive, producing too much hormone.